The series focuses on the work of FBI's New York Fugitive Task Force, which relentlessly tracks and captures the notorious and dangerous criminals on the FBI's Most Wanted list. The fifth season is scheduled to premiere on February 13, 2024. The fourth season premiered on September 20, 2022. In May 2022, CBS renewed the series for a fourth and fifth season. In March 2021, CBS renewed the series for a third season which premiered on September 21, 2021. In May 2020, the series was renewed for a second season which premiered on November 17, 2020. It is the first spin-off from Dick Wolf's drama FBI, in whose first season the characters of the series were introduced.

FBI: Most Wanted is an American crime drama television series created by René Balcer and produced by Wolf Entertainment that was ordered to series by CBS in May 2019.